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Structure-Based Design and Synthesis of Dipeptide Analogues as New Inhibitors of Leucine Aminopeptidase |
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| Authors: | Jolanta Grembecka Artur Mucha Tomasz Cierpicki Paweł Kafarski |
| Institution: | 1. Institute of Organic Chemistry, Biochemistry and Biotechnology , Wroc?aw University of Technology , Wybrzez'e Wyspiańskiego 27, Wroc?aw , 50-370;2. Institute of Biochemistry and Molecular Biology , University of Wroc?aw , Tamka 2, Wroc?aw , 50-137 , Poland |
| Abstract: | The structure-based design, synthesis and activity prediction of new leucine aminopeptidase inhibitors, the phosphonamidate and phosphinate dipeptide analogues are presented. |
| Keywords: | Drug Design Leucine Aminopeptidase Phosphinic Pseudodipeptides Phosphonamidates Protease Inhibitors |