The Synthesis of Some New Sulfur Heterocyclic Compounds as Potential Radioprotective and Anticancer Agents |
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| Authors: | M. M. Ghorab A. N. Osman E. Noaman H. I. Heiba N. H. Zaher |
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| Affiliation: | 1. Department of Drug Radiation Research , National Center for Radiation Research and Technology , Nasr City, Cairo, Egypt;2. Department of Organic Chemistry , Cairo University , Giza, Egypt;3. Department of Radiation Biology , National Center For Radiation Research and Technology , Nasr City, Cairo, Egypt |
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| Abstract: | Some novel 5-subistituted amino-3-methylthiophene-2,4-dicarboxylic acid diethyl ester (3–6), 3,5-dimethyl-4-oxo-2-thioxo-1,2,3,4-tetra-hydro-thieno[2,3-d]pyrimi-dine (7), imidazothienopyrimidene (8), and 1,2,4-triazolo-thienopyrimidine (11) were synthesized via a reaction of the isothiocyanate 2 with different reagents. The identification of the new compounds was established by elemental analysis, and IR, 1H NMR, and mass spectral data. Some prepared compounds were tested for their radioprotective and anticancer activities. Compounds 7 and 16 showed significant activities against EAC cells, while compound 5 exhibited radioprotective activity. |
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| Keywords: | Radioprotective and anticancer activities thieno[2,3-d]pyrimidines |
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