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The Synthesis of Distamycin Analog Containing Phosphonyl Group
Authors:Yong Ye  Shang-Bin Zhong  Ruo-Yu Liu  Li-Feng Cao  Cun-Jiang Liu  Jun-Liang Yang
Institution:1. Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou , China;2. State Key Laboratory of Elemento-Organic Chemistry , Nankai University , Tianjin , 300071 , China;3. Key laboratory of Bioorganic Phosphorus Chemistry &4. Chemical Biology (Ministry of Education) , Tsinghua University , Beijing , China;5. Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou , China
Abstract:In order to obtain high biological activity compound, a series of distamycin analog containing phosphonyl group were synthesized by chloroform reaction and coupling reaction using DCC/HOBT as promoting additives.
Keywords:Biological activity  DNA  distamycin  polyamides
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