THE CONDENSED PHOSPHATES AS INHIBITORS OF THE ZINC-ENZYME CARBONIC ANHYDRASE II |
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| Authors: | Rodica Caprita Adrian Caprita Gheorghe Ilia |
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| Institution: | 1. Banat's University of Agricultural Sciences , Timisoara, Romania;2. Romanian Academy's Institute of Chemistry , Timisoara, Romania |
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| Abstract: | The mobilization of the zinc ion from the zinc enzyme BCA II by the condensed phosphates pyrophosphate (PP), tripolyphosphate (TPP), and higher polyphosphate (HPP) induces the inhibition of the enzymatic activity. The chelating capacity increases with the ligand concentration and with the length of the polyphosphatic chain. The activity is restored when the polyphosphate is hydrolyzed, becoming incapable of chelating the zinc ion, which is able to reform the zinc enzyme. |
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| Keywords: | Carbonic anhydrase higher polyphosphate (HPP) pyrophosphate (PP) tripolyphosphate (TPP) |
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