Pyridazine Derivatives and Related Compounds,Part 28. 1 Pyridazinesulfonamides: Synthesis and Antimicrobial Activity |
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| Authors: | Fatma El-Mariah Ekhlass Nassar Mona Hosny Ali Deeb |
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| Affiliation: | 1. Department of Chemistry, Faculty of Girls , Ain Shams University , Cairo , Egypt;2. Department of Chemistry, Faculty of Science , Zagazig University , Zagazig , Egypt |
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| Abstract: | The reaction of 3-chloropyridazine 1 with N –(un)Substituted 4-aminosulfonamides 3 gave the 3-substituted aminopyridazines 4 . Also In addition, pyridazine-3-sulfonamides 7 were prepared from the reaction of pyridazine-3-sulfonylchloride 6 with different amines. All of these derivatives have been characterized by analytical and spectroscopic studies, and also were tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms. |
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| Keywords: | 3-Substituted aminopyridazines N-substituted pyridazine-3-sulfonamides |
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