Synthesis of Some N1-(3-Hydroxy-2-pyridyl)benzamides

Benzoxazoles are of special interest because of having various types of biological properties such as antihistaminic, antihelmintic antifungal and antibacterial activities. ¹ Hisano, T., Ichikawa, M., Tsumoto, K. and Tasaki, M. 1982. Chem. Pharm. Bull, 30: 2996 CSA]Crossref], Web of Science ®] , Google Scholar], ² Prudhomme, M., Guyot, J. and Jeminet, G. 1986. J. Antibiotics, 39: 934 CSA]Crossref], PubMed], Web of Science ®] , Google Scholar], ³ Ersan, S., Nacak, S., Berkem, R. and Özden, T. 1997. Arzneim. Forsch, 47: 963 CSA]PubMed], Web of Science ®] , Google Scholar], ⁴ Sener, E., Yalc?n, ?., Temeiz, Ö., Ören, ?., Ak?n, A. and Ucartürk, N. 1997. Farmaco, 52: 99 CSA]PubMed] , Google Scholar], ⁵ Ören, ?., Temiz, Ö., Yalc?n, ?., Sener, E., Ak?n and Ucartürk, N. 1997. Forsch, 47: 1393 CSA] Google Scholar], ⁶ Temiz, Ö., Ören, ?., Sener, E., Yalc?n, ?. and Ucartürk, N. 1998. Farmaco, 53: 337 CSA]CROSSREF]Crossref], PubMed] , Google Scholar], ⁷ Yalc?n, ?., Ören, ?., Sener, E., Ak?n, A. and Ucartürk, N. 1992. J. Med. Chem, 27: 401 CSA]CROSSREF]Crossref], Web of Science ®] , Google Scholar], ⁸ Temiz, Ö., Ören, ?. and Altanlar, N. 2002. Farmaco, 57: 175 CSA]CROSSREF]Crossref], PubMed] , Google Scholar], ⁹ Sener, E., Temeiz, Ö., Yalc?n, ?. and Altanlar, N. 2000. Farmaco, 55: 397 CSA]CROSSREF]Crossref], PubMed] , Google Scholar], ¹⁰ Ören, ?., Temiz, Ö., Yalc?n, ?., Sener, E. and Altanlar, N. 1998. Eur. J. Pharm. Sci., 7: 153 CSA]Crossref], Web of Science ®] , Google Scholar] Benzamide derivatives, as the possible metabolites of benzoxazoles, show various types of biological activities. ¹¹ Sener, E., Bingöl, K., Ören, ?., Arpac?, Ö., Yalc?n, K. ?. and Altanlar, N. 2000. Farmaco, 55: 469 CSA]CROSSREF]Crossref], PubMed] , Google Scholar], ¹² Sener, E., Yalc?n, K. ?. and Altanlar, N. 2002. Farmaco, 57: 451 CSA]CROSSREF]Crossref], PubMed] , Google Scholar] Some N-(2-hydroxyphenyl)- benzamides, which showed significant activity compared to phenylacetamides and furamides,11 have been synthesized by treating 2-aminophenol with carboxylic acid chlorides under weak basic solution. ¹¹ Sener, E., Bingöl, K., Ören, ?., Arpac?, Ö., Yalc?n, K. ?. and Altanlar, N. 2000. Farmaco, 55: 469 CSA]CROSSREF]Crossref], PubMed] , Google Scholar], ¹² Sener, E., Yalc?n, K. ?. and Altanlar, N. 2002. Farmaco, 57: 451 CSA]CROSSREF]Crossref], PubMed] , Google Scholar] However, synthesis and especially biological activity of N-(3-hydroxy-2-pyridyl)benzamides were not studied well. Owing to the versatility of benzamides we have extended the reaction of 2-amino-3-pyridinol with different carboxylic acid chlorides in order to preparation of some new benzamide derivatives containing a hydroxypyridyl ring.