Synthesis and Antioxidant,Anti-Inflammatory,and Analgesic Activity of Novel Polycyclic Pyrimido[4,5-b]quinolines |
| |
| Authors: | A. B.A. El-Gazzar H. N. Hafez A. A. Abu-Hashem A. S. Aly |
| |
| Affiliation: | Photochemistry Department (Heterocyclic and Nucleosides Unit) , National Research Centre , Dokki, Giza, Egypt |
| |
| Abstract: | The behavior of the 2-methylthio-pyrimido[4,5-b]quinolin-4-one towards differently substituted amines is reported. Also, the reactivity of 3-aminothiazolo[3′,2′ :1,2]-pyrimido[4,5-b]quinoline-2-carbonitrile towards formic acid, urea, thiourea, formamide, and carbon disulfide is discussed. Some of the synthesized derivatives possess biological activities as anti-inflammatory and analgesic agents. Some of these selective biologically active compounds were screened for antioxidant properties. |
| |
| Keywords: | 3-Aminothiazolo-[3′,2′:1,2]pyrimido[4,5-b]quinoline-2-carbonitrile analgesic activities anti-inflammatory antioxidant 2-arylaminopyrimido[4,5-b]quinoline 2-methylthio |
|
|
