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A Synthetic Pathway to Cys-Xxx-Cys (N2S2) Analogue Ligands: An Improved Synthesis of HSCH2CH2C(O)NHCH2C(O)NHCH2CH2SH |
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| Authors: | Jennifer K Angelosante Breia J Lewis Lisa E Cooper Rebecca A Swanson Christopher J A Daley |
| Institution: | Department of Chemistry , Western Washington University , Bellingham , Washington |
| Abstract: | Herein, two improved synthetic pathways to biologically relevant Cys-Xxx-Cys analogue ligands used in conjunction with metals as metalloenzyme models (Ni for carbon monoxide dehydrogenase/acetyl-CoA synthase A-cluster; Co and Fe for nitrile hydratase) are reported. |
| Keywords: | Carboxamido ligand metal thiolate peptide synthesis synthetic analogue |