Novel Green Procedure for the Synthesis of 2-Arylbenzothiazoles Under Microwave Irradiation in Peg 200 Or Peg 400 |
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| Authors: | Todor G Deligeorgiev Stefka Kaloyanova Aleksey Vasilev Juan J Vaquero |
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| Institution: | 1. Faculty of Chemistry , University of Sofia , Sofia , Bulgaria;2. Facultad de Farmacia, Universidad de Alcalá , Alcalá de Henares , Madrid , Spain |
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| Abstract: | An improved green procedure for the synthesis of 2-aryl- and 2-hetarylbenzothiazoles by condensation of equivalent amounts of 2,2′-diaminodiphenyldisulfides or 2-aminothiophenols and various aromatic aldehydes in PEG 200/400 under microwave irradiation has been developed. This method allows the synthesis of 2-arylbenzothiazoles in high yields and with high purity regardless of the state of the starting compounds (liquid or solid) or the nature of the substituents in the aromatic ring. |
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| Keywords: | 2-Aminothiophenols arylbenzothiazoles 2 2′-diaminodiphenyldisulfides green chemistry microwave |
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