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The Reaction of Cyclohexan-1,3-dione with Cyanomethylenes: Synthesis of Thiophenes and Their Fused Derivatives with Antifungal Activities |
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| Authors: | Rafat M Mohareb Sherif M Sherif Hosam El-Dean Moustafa |
| Institution: | 1. Department of Organic Chemistry, Faculty of Pharmacy , October University for Modern Sciences and Arts (MSA) , October, A. R., Egypt;2. Department of Chemistry, Faculty of Science , Cairo University , Giza, A. R., Egypt;3. Department of Chemistry, Faculty of Science , Cairo University , Giza, A. R., Egypt |
| Abstract: | Abstract 2-Amino-7-oxotetrahydrobenzob]thiophenes 3a,b were prepared according to the Gewald procedure. Their reactivity toward a variety of chemical reagents was studied to give annulated heterocycles with potential bio-responses. |
| Keywords: | Annulated derivatives pyridine thiazole thiophene |