A Fast and Large-Scale Synthesis of 3-Formyl-2-mercaptoquinolines |
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| Authors: | Belalakatte P Nandeshwarappa Doyijode B Aruna Kumar Halehatty S Bhojya Naik Kittappa M Mahadevan |
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| Institution: | 1. Department of Post Graduate Studies and Research in Industrial Chemistry , Kuvempu University , Shankaraghatta , Karnataka , India;2. Department of PG Studies and Research in Chemistry , Kuvempu University , Shankaraghatta , Karnataka , India |
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| Abstract: | A convenient, efficient, and inexpensive procedure for the synthesis of 3-formyl-2-mercaptoquinolines 2a–l has been developed by a simple one-pot reaction of 3-formyl-2-chloroquinolines 1a–l with sodium sulfide and hydrochloric acid in ethanol. The structures of all the synthesized compounds were elucidated on the basis of elemental analyses and IR, 1 H NMR, and mass spectral data. |
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| Keywords: | 3-formy-2-mercaptoquinoline 3-formy-2-chloroquinoline hydrochloric acid sodium sulfide |
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