An Efficient Synthesis of New 3,4-Dihydropyrimidin- 2(1H)-ones Incorporating a Phenyl Moiety at C-5 and C-6 Catalyzed by TMSCl and Co(OAc)2.4H2O |
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| Authors: | Hassan Kefayati Maryam Fakhriyannejad Ali A. Mohammadi |
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| Affiliation: | 1. Department of Chemistry , Islamic Azad University , Bandar Anzali Branch, Iran;2. Department of Chemistry , Shahid Beheshti University , Tehran, Iran |
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| Abstract: | New 3,4-dihydropyrimidin-2-ones having a phenyl moiety at C-5 and C-6 have been prepared by a microwave-assisted Biginelli–like reaction by a three-component, one-pot condensation of an aromatic aldehyde, deoxybenzoin and urea, or thiourea using TMSCl and Co(OAc) 2 .4H 2 O as an efficient Lewis acid catalyst. |
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| Keywords: | Biginelli–like reaction Co(OAc)2.4H2O 3,4-dihydropyrimidin-2-one microwave-assisted TMSCl |
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