In silico evolution of substrate selectivity: comparison of organometallic ruthenium complexes with the anticancer drug cisplatin |
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| Authors: | Deubel Dirk V Lau Justin Kai-Chi |
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| Affiliation: | ETH Zurich, USI Campus, Computational Science, Via Guiseppe Buffi 13, CH-6900, Lugano, Switzerland. metals-in-medicine@phys.chem.ethz.ch |
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| Abstract: | A comparative quantum chemical approach helps to clarify how the selectivity of anticancer metallopharmaceuticals towards potential biological targets can be controlled by metal and ligands. |
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