Spin-Echo planar spectroscopic imaging for fast lipid characterization in bone marrow. |
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| Authors: | S Bao C R Guttmann J P Mugler J R Brookeman L P Panych R A Kraft K Oshio D Jaramillo F A Jolesz D S Williamson R V Mulkern |
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| Institution: | Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. |
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| Abstract: | Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two-dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition. |
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