多羟基吡咯烷衍生物的立体选择性合成

以D-木糖及D-葡萄糖为原料, 经具有降冰片结构的双环缩醛中间体, 合成了适当羟基保护的五元环氮杂糖衍生物及其氟代衍生物, 进一步探讨了含氮杂糖结构的双糖衍生物的合成.

Stereoselective Synthesis of Derivatives of Polyhydroxylated Pyrrolidines

The derivatives of polyhydroxylated pyrrolidines have exhibited a remarkable biological activity to inhibit glycoside-processing enzymes,and found a potential chemotherapeutic applications against diabetes,cancer,and viral infections including AIDS.And great attention has been attracted to the synthesis of their new derivatives and analogues.In this paper,some new derivatives of 5-membered azasugars with partially protected hydroxy groups,and their fluorinated ones were synthesized via the key intermediate of norbonyl like bicyclic acetal with D-xylose and Dglucose as the starting materials.The glycosylation of the synthesized partially protected azasugar and 1-methylenesugar was explored.