Enzyme inhibiting lignans from Vitex negundo |
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| Authors: | Azhar-Ul-Haq Malik Abdul Anis Itrat Khan Sher Bahadar Ahmed Ejaz Ahmed Zaheer Nawaz Sarfraz Ahmad Choudhary Muhammad Iqbal |
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| Affiliation: | International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. |
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| Abstract: | Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase. |
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