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Preparation and Non-Invasive In-Vivo Imaging of Anti-Adhesion Barriers with Fluorescent Polymeric Marks |
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| Authors: | Shih-Rong Hsieh Chi-Jung Chang Tzong-Der Way Po-Cheung Kwan Tsung-Wei Hung |
| Institution: | (1) Department of Chemical Engineering, Feng Chia University, 100, Wenhwa Road, Seatwen, Taichung, 40724, Taiwan;(2) Department of Surgery, Taichung Veterans General Hospital, Taichung, 40724, Taiwan;(3) Department of Pathology, Taichung Veterans General Hospital, Taichung, 40724, Taiwan;(4) School of Biological Science and Technology, College of Life Science, China Medical University, Taichung, 40724, Taiwan |
| Abstract: | Comb-like PEMLn polymers with pendent PEG-PLLA side chains were synthesized as tissue anti-adhesion barriers. The comb-like structure improved the flexibility of the films. Fluorescent polymer-biocompatible polymer guest-host materials were printed on the films as marking dots. Without sacrificing rats on different days after surgery, degradation behaviors of the marked films can be investigated non-invasively in the in-vivo imaging system (IVIS) by monitoring the location of fluorescent signals. Degradation properties of PEML1/G26L35 films were adjusted by incorporating G26L35 oligomers. PEML1 and PEML1/G26L35 films were very effective in preventing post-surgical tissue-adhesions. Degradation behaviors of various films observed in the animal study were consistent with those investigated by the in-vivo imaging method. Fluorescent polymer/biocompatible polymer blends were promising candidates for in-vivo imaging applications. |
| Keywords: | In-Vivo imaging Non-invasive Anti-adhesion Fluorescent polymer Fluorescence |
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