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| 二丁基氧化锡脱脂肪族糖苷乙酰保护基的研究 | |
| 引用本文： | 王少敏,李娟,李华雨,刘宏民,李雯. 二丁基氧化锡脱脂肪族糖苷乙酰保护基的研究[J]. 有机化学, 2008, 28(1): 120-122 |
| 作者姓名： | 王少敏 李娟 李华雨 刘宏民 李雯 |
| 作者单位： | 1. 郑州大学化学系,郑州,450052;郑州大学新药研究开发中心,郑州,450052 2. 郑州大学化学系,郑州,450052 3. 郑州大学新药研究开发中心,郑州,450052 4. 郑州大学化工学院,郑州,450052 |
| 摘 要： | 研究了以二丁基氧化锡为催化剂, 在甲醇溶剂中, 含有不同官能团的脂肪族糖苷的脱乙酰保护基反应. 结果表明采用该方法可以选择地得到糖上全部或部分脱乙酰保护基产物, 并且脱保护产物的立体构型保持, 没有分解现象发生. 该方法具有操作简单、反应条件温和、产率高等特点. |
| 关 键 词： | 二丁基氧化锡 脱乙酰作用 立体选择性 脂肪族糖苷 |
| 收稿时间： | 2007-02-07 |
| 修稿时间： | 2007-07-09 |
Deacetylation Method of Aliphatic Glycosides Catalyzed byDibutyltin Oxide |
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| WANG,Shao-Min,LI,Juan,LI,Hua-Yu,LIU,Hong-Minb,LI,Wen. Deacetylation Method of Aliphatic Glycosides Catalyzed byDibutyltin Oxide[J]. Chinese Journal of Organic Chemistry, 2008, 28(1): 120-122 | |
| Authors: | WANG Shao-Min LI Juan LI Hua-Yu LIU Hong-Minb LI Wen |
| Affiliation: | ( Department of Chemistry, Zhengzhou University, Zhengzhou 450052)(New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450052)( School of Chemical Engineering, Zhengzhou University, Zhengzhou 450052) |
| Abstract: | Deprotection of acetylated glycoside in the presence of catalytic amounts of dibutyltin oxide in methanol was described. Acetyl groups in these glycosides could be smoothly and selectively deprotected in good yields without obvious isomerizations or degradations of the sugar part under the reaction conditions. Compared to the previous methods, this new method has the advantages of simple procedure, mild conditions and high yields. |
| Keywords: | dibutyltin oxide deacetylation regioselectivity aliphatic glycoside |
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