| 低共熔溶剂促进2,4,6-三芳基吡啶的有效合成 |
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| 引用本文： | 刘光仙,肖立伟,冉贺欣,孔洁.低共熔溶剂促进2,4,6-三芳基吡啶的有效合成[J].化学研究与应用,2021,33(1):205-208. |
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| 作者姓名： | 刘光仙 肖立伟 冉贺欣 孔洁 |
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| 作者单位： | 廊坊师范学院化学与材料科学学院,河北 廊坊 065000;廊坊师范学院化学与材料科学学院,河北 廊坊 065000;廊坊师范学院化学与材料科学学院,河北 廊坊 065000;廊坊师范学院化学与材料科学学院,河北 廊坊 065000 |
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| 基金项目： | 廊坊市科技局项目(2019011018)资助;河北省教育厅重点项目(ZD2020153)资助。 |
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| 摘 要： | 2,4,6-三芳基吡啶是一类重要的杂环化合物,在多个领域有广泛的应用。本文在氯化胆碱/对甲苯磺酸组成的低共熔溶剂中,以芳香酮、芳香醛、乙酸铵为原料,微波辐射下一锅合成了一系列2,4,6-三芳基吡啶,产率74.6~90.7%,产物结构经^1H NMR、^13 C NMR表征。该法具有反应条件温和、操作简单、产率较高、耗时短、绿色环保等优势。
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| 关 键 词： | 2 4 6-三芳基吡啶 低共熔溶剂 微波辐射 一锅法 |
An efficient synthesis of 2,4,6-triarylpyrid-ines in deep eutectic solvent |
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| LIU Guang-xian,XIAO Li-wei,RAN He-xin,KONG Jie.An efficient synthesis of 2,4,6-triarylpyrid-ines in deep eutectic solvent[J].Chemical Research and Application,2021,33(1):205-208. |
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| Authors: | LIU Guang-xian XIAO Li-wei RAN He-xin KONG Jie |
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| Institution: | (College of Chemistry and Material Science,Langfang Normal University,Langfang 065000,China) |
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| Abstract: | As an important class of heterocyclic compounds,2,4,6-triarylpyridines have been applied in many fields.A series of 2,4,6-triarylpyridines were synthesized from aromatic ketones,aryl aldehydes and ammonium acetate in deep eutectic solvent composed by choline chloride and p-toluensulfonic acid under microwave irradiation conditioninyields of 74.6~90.7%.The structure of the products was indentified by 1H-NMR and 13 C-NMR spectroscopy.This method had several advantages such aseasy work up,short reaction time,environmental friendliness and high yields. |
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| Keywords: | 2 4 6-triarylpyridines deep eutectic solvent microwave radiation one-pot method |
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