One-pot synthesis,characterization, and drug loading of polysaccharide-based nanoparticles with carboxy functional groups |
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| Authors: | Hongjing Dou Minhua Tang Weihai Yang Kang Sun |
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| Institution: | (1) School of Materials Science and Engineering, and State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, People’s Republic of China |
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| Abstract: | Herein, various polysaccharide-based nanoparticles were synthesized from dextran, hydroxypropyl cellulose, and hydroxyethyl
cellulose, respectively, by a self-assembly assisted approach. This approach enables us to prepare stable polysaccharide-based
nanoparticles with carboxy functional groups directly from monomers without using any surfactant and organic solvent. The
existence of abundant carboxyls in these polysaccharide-based nanoparticles provides them obvious pH sensitivity as verified
by 1H nuclear magnetic resonance as well as the potential in loading cationic drug. |
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| Keywords: | Nanoparticle Polysaccharide Self-assembly Carboxyl |
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