Synthesis and antimicrobial activity of quinoline-based 2-pyrazolines |
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Authors: | Munawar A. Munawar Muhammad Azad Makshoof Athar Paul W. Groundwater |
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Affiliation: | (1) Institute of Chemistry, University of the Punjab, 54590 Lahore, Pakistan;(2) Pharmacy School University of Sunderland, SR1 3SD Sunderland, UK |
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Abstract: | A series of 2-pyrazolines was prepared in a reaction of quinolinylchalcones with phenyl hydrazine under both conventional and microwave-induced heating. Structures of the synthesized compounds were characterized by spectroscopic data and CHN analyses. All prepared compounds were tested for antimicrobial activity against bacterial strains, viz. Staphylococcus aureus, Salmonella typhii, Escherichia coli, and Shigella dysentery. Almost all synthesized compounds have shown antimicrobial activity; however, compounds with a chloro group as a substituent have been found to be more effective. |
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Keywords: | pyrazolines chalcones N-substituted 3-acetyl-4-hydroxyquinolin-2(1H)-one antimicrobial activity |
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