One-pot efficient green synthesis of 1,4-dihydro-quinoxaline-2,3-dione derivatives |
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| Authors: | Harjyoti Thakuria and Gopal Das |
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| Affiliation: | (1) Department of Chemistry, Indian Institute of Technology Guwahati, 781 039 Guwahati |
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| Abstract: | An efficient synthesis of the potential pharmacophore 1,4-dihydro-quinoxaline-2,3-dione (1) has been achieved in a one-pot reaction at room temperature from substitutedo-phenylene diamine and oxalic acid under solvent-free conditions by a simple grinding method with unsurpassed atom economy. Thermal and powder X-ray diffraction analysis was carried out for some hydrated crystals. |
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| Keywords: | Green chemistry quinoxaline o-phenylene diamine oxalic acid grinding atom economy |
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