Highly regioselective intermolecular hydroacylations of enamides with salicylaldehydes |
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Authors: | Zhang Hui-Jun Bolm Carsten |
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Institution: | Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany. |
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Abstract: | Highly regioselective intermolecular hydroacylations of enamides under rhodium catalysis with monodentate phosphane ligands are reported for the first time. The presence of MeCN facilitates this novel C-C bond formation, and the electron-deficient phosphine P(p-F-Ph)(3) has proven most effective for the direct hydroacylation of 1-vinyl-2-pyrrolidinone. Accordingly, an atom-economic synthetic route to α-amido ketones from readily available substrates has been developed. |
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