Triplex formation with alpha-L-LNA (alpha-L-ribo-configured locked nucleic acid) |
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| Authors: | Kumar Niti Nielsen Katrine E Maiti Souvik Petersen Michael |
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| Affiliation: | Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, 5230 Odense M, Denmark. |
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| Abstract: | Using UV melting and CD spectroscopy, we show that alpha-l-LNA-modified oligonucleotides possess the ability to form triplexes at pH 6.8 with significantly increased thermostability relative to DNA triplexes. |
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