Spirocurcasone, a diterpenoid with a novel carbon skeleton from Jatropha curcas |
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Authors: | Chianese Giuseppina Fattorusso Ernesto Aiyelaagbe Olapeju O Luciano Paolo Schröder Heinz C Müller Werner E G Taglialatela-Scafati Orazio |
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Affiliation: | Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano, 49, I-80131 Napoli, Italy. |
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Abstract: | Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line. |
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