Plasticity of histamine H<Subscript>3</Subscript>receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Plasticity of histamine H3receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat

Authors:	Adrian?F?Lozada,Antti?A?Aarnisalo,Kaj?Karlstedt,Holger?Stark,Pertti?Panula author-information" > author-information__contact u-icon-before" > mailto:pertti.panula@abo.fi" title=" pertti.panula@abo.fi" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	1.Department of Biology,?bo Akademi University, Biocity,Turku,Finland;2.Department of ORL, HUCH,Helsinki,Finland;3.Johann Wolfgang Goethe-Universit?t Frankfurt am Main,Institut für Pharmazeutische Chemie,Biozentrum,Germany;4.Institute of Biomedicine/Anatomy,University of Helsinki,Finland

Abstract:	Background In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g., diminished symptoms), encompassing 1 week after unilateral labyrinthectomy, has been termed vestibular compensation. Evidence suggesting that the histamine H₃ receptor plays a key role in vestibular compensation comes from studies indicating that betahistine, a histamine-like drug that acts as both a partial histamine H₁ receptor agonist and an H₃ receptor antagonist, can accelerate the process of vestibular compensation.

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Background