| 氟哌酸β-环糊精包结配合物的研究 |
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| 引用本文： | 陈亮. 氟哌酸β-环糊精包结配合物的研究[J]. 波谱学杂志, 1998, 15(3): 243-248 |
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| 作者姓名： | 陈亮 |
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| 作者单位： | 1. 山西大学分析测试中心, 太原 030006;2. 山西大学化学系, 太原 030006 |
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| 基金项目： | 山西省自然科学基金,山西省留学人员基金 |
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| 摘 要： | 氟哌酸是一种广谱、安全、有效,可供口服的抗感染药.我们通过荧光光谱、1H NMR、13C NMR等技术对氟哌酸与β-环糊精(β-CD)的相互作用进行了研究,证明氟哌酸和β-CD形成了包结配合物.包结配合物的生成常数由1D NMR和荧光光谱测量而确定,并由改进的Be-nesi-Hildebrand方法进行了计算,根据这些数据提出了包结配合物的空间构型.
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| 关 键 词： | 氟哌酸 β-环糊精 荧光 NMR |
| 收稿时间： | 1997-11-28 |
STUDIES OF NORFLOXACIN WITH β-CYCLODEXTRIN INCLUSION COMPLEX |
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| Chen Liang a,Wang Baojun b and Huang Shuping a. STUDIES OF NORFLOXACIN WITH β-CYCLODEXTRIN INCLUSION COMPLEX[J]. Chinese Journal of Magnetic Resonance, 1998, 15(3): 243-248 |
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| Authors: | Chen Liang a Wang Baojun b Huang Shuping a |
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| Affiliation: | 1. The Test and Analysis Center, Shanxi University, Taiyuan 030006;2. Chemistry Department, Shanxi University, Taiyuan 030006 |
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| Abstract: | The norfloxacin is an effective and safe anti-infective with broadspectrum, and can be taken orally. The interaction of norfloxacin with β-CD has been studied by several analytical techniques, including 1D 1H NMR, 13C NMR, and fluorescence spectra. The experimental results confirmed the existence of a 1:1 inclusion complex of norfloxacin and β-CD. The formation constant of the complex was determined by use of 1D NMR data, a modified Benesi-Hildebrand procedure was employed to calculate the formation constant. A spacial configuration of the complex has been proposed based on these date. |
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| Keywords: | Norfloxacin β-cyclodextrin NMR Fluorescence spectrum |
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