One-electron reduction of excited NMN+ and NADP+ in the presence of amino acids |
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| Affiliation: | 1. Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100193, China;2. Institute of Medical Information, Chinese Academy of Medical Sciences, Beijing, 100020, China;1. Empa Swiss Federal Laboratories for Material Science and Technology, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland;2. University of Lausanne, Centre of Public Law & IDHEAP | Swiss Graduate School of Public Administration, 1015, Lausanne, Switzerland;3. University of St. Gallen, Institute of Management, Dufourstrasse 40A, 9000, St. Gallen, Switzerland;4. University of Lausanne, IDHEAP | Swiss Graduate School of Public Administration, 1015, Lausanne, Switzerland;1. Victoria University Business School (VUBS), Victoria University, Melbourne, Victoria 3000, Australia;2. Department of Business, Management and Finance, Melbourne Polytechnic, Victoria 3072, Melbourne, Australia;1. School of Management, China University of Mining and Technology, Xuzhou, Jiangsu Province, 221116, China;2. Research Center for Energy Economics, School of Business Administration, Henan Polytechnic University, Jiaozuo, Henan Province, 454000, China;1. College of Management, Yuan Ze University, Taoyuan City, Taiwan;2. College of Technology Management, National Tsing Hua University, Hsinchu City, Taiwan |
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| Abstract: | Excitation of oxidized forms of nicotinamide coenzymes (NADP+, NMN+) at 254 nm under anaerobic conditions in the presence of EDTA, lysine, serine, glycine leads, in the initial stage of irradiation, to photoreduction of coenzyme. Formation of the photoreduction products was observed by polarographic, spectrophotometric and enzymatic methods. Quantum yields for NMN+ and NADP+ photoreduction have been calculated and a mechanism proposed. No photoreduction was observed with histidine. Long-term irradiation leads to further reduction of the nicotinamide ring to tetrahydroderivatives absorbing at 280–290 nm. The photochemically generated dimers undergo phototransformation to the parent monomers on irradiation at 365 nm either in the presence or absence of oxygen. The biological significance of the results is discussed. |
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