Fast and precise automatic baseline correction of one- and two-dimensional nmr spectra

A universally applicable automatic procedure for the baseline correction of NMR spectra is presented. It relies on baseline recognition in the first derivative of the spectrum which does not contain any baseline distortion. The recognized baseline of the original spectrum is then fitted to a polynomial of fifth degree and may be subtracted from the spectrum. Subsequent application to all rows and columns of 2D spectrum may reveal valuable additional information from small cross peaks. Results are presented for the application to a phase-sensitive ROESY spectrum of Cyclosporin A.