Rhodium-catalysed asymmetric hydrosilylation of ketones using HETPHOX ligands |
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Authors: | Anthony G Coyne |
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Institution: | Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield Dublin 4, Ireland |
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Abstract: | The HETPHOX ligand class was applied to the rhodium-catalysed asymmetric hydrosilylation of a range of substituted acetophenones. Enantioselective hydrosilylation of acetophenone with the tert-butyl substituted HETPHOX ligand gave (R)-phenylethanol in excellent enantioselectivity (84% ee) and in good conversion (80%). When applied to the hydrosilylation of other ketones conversions up to 93% and enantioselectivities up to 88% were observed. |
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