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Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates |
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| Authors: | Sang-ho Ma Hyun-Joon Ha Won Koo Lee |
| Affiliation: | a Department of Chemistry, Hankuk University of Foreign Studies, Yongin, Kyunggi-Do 449-791, Republic of Korea b Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121-742, Republic of Korea |
| Abstract: | Enantiopure 1-phenylethylazetidine-2-carboxylates and 2-acylazetidines were prepared and reacted with chloroformates to yield α-chloro-γ-amino butyric acid esters and ketones from ring opening reaction of azetidinium ion intermediate in a completely regio- and stereoselective manner. |
| Keywords: | Azetidine-2-carboxylate 2-Acylazetidine Chloroformate Ring opening α-Chloro-γ-amino butyric acid esters |
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