Stille coupling approaches for the synthesis of 8-aryl guanines |
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| Authors: | Pavel Arsenyan Martins Ikaunieks Sergey Belyakov |
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| Institution: | Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia |
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| Abstract: | The reaction of 8-bromoguanines with aryl and hetaryl stannanes in the presence of a palladium catalyst leads to the formation of the corresponding 8-aryl(hetaryl)guanines. It was found that the addition of triphenylarsine or triphenylbismuth strongly reduces the reaction time and increases product yields. |
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| Keywords: | Arsine Bismuth Guanine Palladium Stille coupling |
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