Synthesis, isolation, and characterization of ABT-578 equilibrium isomers |
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Authors: | Madhup K Dhaon Sanjay Chemburkar Howard Morton |
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Institution: | Process Research and Development, Global Pharmaceuticals Research and Development, Abbott Laboratories, 1401 N. Sheridan Road, North Chicago, IL 60064, USA |
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Abstract: | ABT-578, an anti-restenosis agent exists as two isomers, a major pyran form and a minor oxepane form. The existence of the two isomeric forms was established by isolation and equilibration studies under buffered and physiological conditions. Finally their structures were confirmed by converting the major pyran form to the oxepane form by synthesis, isolation, and characterization. |
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Keywords: | Pyran Oxepane Isomers Rapamycin analog |
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