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Synthesis of diarylazepan-4-ones |
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| Authors: | Meng-Yang Chang Yung-Hua Kung Chih-Chong Ma |
| Institution: | Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung 811, Taiwan |
| Abstract: | Synthesis of several 3,3-diarylazepan-4-ones and 5,5-diarylazepan-4-ones has been established starting from two tetrasubstituted olefins, which is derived from commercially available piperidine-3-carboxylic acid ethyl ester and piperidine-4-carboxylic acid ethyl ester. The single isomer with the structural skeleton of 3,3-diarylazepan-4-one and 5,5-diarylazepan-4-one is constructed in two functional group transformations of Grignard addition/dehydration and epoxidation/pinacol rearrangement. |
| Keywords: | Diarylazepan-4-ones m-Chloroperoxybenzoic acid Boron trifluoride etherate Grignard addition/dehydration Epoxidation/pinacol rearrangement |
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