Synthesis of 4-carboxy-4-pyridylpiperidines through palladium-catalyzed α-arylation of esters |
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| Authors: | Yong Wang Reji Nair |
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| Affiliation: | a Diabetes Chemistry, La Jolla Laboratories, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, CA 92121, USA
b San Diego State University, San Diego, CA 92182, USA |
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| Abstract: | A concise synthesis of 4-carboxy-4-pyridylpiperidines has been achieved. Key step is the palladium-catalyzed α-arylation of esters under basic conditions. |
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