First total synthesis of topopyrone C |
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| Authors: | Sonia Gattinoni |
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| Institution: | Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, via Celoria 2, 20133 Milano, Italy |
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| Abstract: | The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been carried out by Marschalk alkylation of 1-hydroxy-3,6,8-trimethoxyanthraquinone, followed by a Baker-Venkataraman chain elongation and an acid-catalyzed cyclization for the construction of the pyrone ring. |
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| Keywords: | Topopyrone C Synthesis Anthraquinone Topoisomerase Marschalk reaction |
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