Polystyrene-supported proline and prolinamide. Versatile heterogeneous organocatalysts both for asymmetric aldol reaction in water and α-selenenylation of aldehydes |
| |
Authors: | Francesco Giacalone Adriana Mossuto Marculescu Renato Noto |
| |
Affiliation: | Dipartimento di Chimica Organica ‘E. Paternò’, Università di Palermo, Viale delle Scienze, Parco d’Orleans, Pad. 17, I-90128 Palermo, Italy |
| |
Abstract: | A simple and efficient synthesis of polystyrene-supported proline and prolinamide has been carried out. Polystyrene-supported proline has been used as organocatalyst in the asymmetric aldol reaction between cyclohexanone and substituted benzaldehydes in water without any additive. High yields, diastereoselectivities and ee values have been observed. The versatility of this resin was demonstrated in the α-selenenylation of aldehydes. Both proline and prolinamide resins gave high yields. Recycling studies showed that the proline resin gave better results than prolinamide resin. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|