Erlenmeyer azlactone synthesis with aliphatic aldehydes under solvent-free microwave conditions |
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Authors: | Sosale Chandrasekhar Phaneendrasai Karri |
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Institution: | Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India |
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Abstract: | 2-Phenyl-5(4H)-oxazolone (azlactone) reacts with aliphatic aldehydes upon adsorption on neutral alumina and irradiation with microwaves (<2 min). The corresponding condensation products are obtained in good yields (62-78%), indicating the satisfactory resolution of a long-standing problem plaguing the classical Erlenmeyer synthesis (poor results with aliphatic aldehydes). Plausible mechanistic reasons for the success of the procedure are discussed. |
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Keywords: | Aliphatic aldehydes Alumina Azlactones Erlenmeyer synthesis Microwave Oxazolone Solvent-free |
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