A convenient synthesis of 6,6′-dimethyl-2,2′-bipyridine-4-ester and its application to the preparation of bifunctional lanthanide chelators |
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| Authors: | Fabien Havas |
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| Affiliation: | Laboratoire de Synthèse et Physicochimie de Molécules d’Intérêt Biologique—UMR CNRS 5068, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France |
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| Abstract: | We describe a convenient scalable synthesis of 4-carbomethoxy-6,6′-dimethyl-2,2′-bipyridine based on the application of modified Negishi cross-coupling conditions. The use of this building block in the preparation of a number of dissymmetrically 6,6′-trisubstituted-2,2′-bipyridines and of bifunctional lanthanide chelators is also reported. |
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| Keywords: | Bipyridine Bifunctional chelators Lanthanides |
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