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Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones |
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| Authors: | Zhang Wei Williams John P Lu Yimin Nagashima Tadamichi Chu Qainli |
| Institution: | a Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, PA 15238, USA b Neurocrine Biosciences, 12790 El Camino Real, San Diego, CA 92130, USA |
| Abstract: | A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for the synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE). |
| Keywords: | Sclerotigenin Benzodiazepine-quinazolinone 1 4-Benzodiazepine-2 5-dione Fluorous synthesis Solid-phase extraction |
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