Pictet-Spengler reactions catalyzed by Brønsted acid-surfactant-combined catalyst in water or aqueous media |
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| Authors: | Akio Saito |
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| Institution: | Laboratory of Organic Reaction Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan |
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| Abstract: | Perfluorooctanesulfonic acid (PFOSA), Brønsted acid-surfactant-combined catalyst, efficiently catalyzes the Pictet-Spengler reactions of β-arylethyl carbamate derivatives with aldehydes in water. The present reaction is accelerated by the addition of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). |
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| Keywords: | Surfactant Brø nsted acid Pictet-Spengler reaction Carbamate Isoquinoline |
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