N-Alkyl cysteine-assisted thioesterification of peptides |
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Authors: | Hironobu Hojo |
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Affiliation: | Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa, 259-1292, Japan |
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Abstract: | A new method for the preparation of peptide thioester by the post-solid phase peptide synthesis (SPPS) approach was developed. A series of N-alkyl cysteine derivatives were prepared and used as the C-terminus residue of the peptides prepared by the Fmoc SPPS. The synthetic peptides released from resin by TFA were readily converted to the peptide thioester in aqueous 3-mercaptopropionic acid (MPA) without significant side reactions. |
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Keywords: | Fmoc solid-phase method N-S Acyl transfer Peptide thioester |
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