Enantioselective synthesis of (R) and (S)-[9,9′]bi[naphtho(2,1-b)furanyl]-8,8′-diol: a furo-fused BINOL derivative |
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| Authors: | Sunil P Upadhyay |
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| Institution: | Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Mumbai 400 098, India |
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| Abstract: | The enantioselective synthesis of 9,9′]binaphtho(2,1-b)furanyl]-8,8′-diol, a modified BINOL, was achieved using an inexpensive route. Both enantiomers of 9,9′]binaphtho(2,1-b)furanyl]-8,8′-diol were obtained with satisfactory stereoselectivities by employing two optical antipodes of phenylethylamine as chiral influence in a Cu(II)Cl2 catalyzed oxidative coupling step. |
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| Keywords: | Modified BINOL Chiral HPLC Oxidative coupling Phenylethylamine |
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