Synthesis of substituted tetralones as intermediates of CNS agents via palladium-catalyzed cross-coupling reactions |
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| Authors: | Marí a Torrado |
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| Affiliation: | Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain |
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| Abstract: | A series of substituted tetralones as intermediates of CNS agents has been synthesized via Pd-catalyzed coupling reactions of 3-(methoxycarbonyl)-1,2,3,4-tetrahydro-1-oxonaphthalen-6-yl trifluoromethanesulfonate (5) with a variety of organometallic reagents. |
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| Keywords: | Palladium-catalyzed coupling reactions Stille Suzuki Sonogashira Cyanation |
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