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Fast deprotection of phenoxy benzyl ethers in transfer hydrogenation assisted by microwave |
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| Authors: | Monica Quai Claudio Repetto Enzo Cereda |
| Institution: | a Chemistry Research Centre, Boehringer Ingelheim Italia, Via Lorenzini 8, Milano, Italy b Organic Chemistry Department, Rotta Research Laboratorium, Via Valosa di Sopra 7, Monza, Italy |
| Abstract: | Phenoxy benzyl ethers are easily and quickly deprotected in the presence of ammonium formate and microencapsulated Pd(0)EnCat with the assistance of microwave irradiation. This procedure can be applied in the presence of other functional groups as well. The described protocol is particularly convenient for the preparation in a parallel and automatic fashion of libraries of compounds possessing a phenol type moiety. |
| Keywords: | Transfer hydrogenation Microwave chemistry Debenzylation Microincapsulated catalysts |
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