A new method for the preparation of 2-chlorotrityl resin and its application to solid-phase peptide synthesis |
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| Authors: | Tae-Kyung Lee Yoon-Sik Lee |
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| Affiliation: | a School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea
b BeadTech Inc., Institute for Chemical Processes, Seoul National University, Seoul 151-744, Republic of Korea |
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| Abstract: | 2-Chlorotritylchloride (2-CTC) resin was prepared efficiently from 1% DVB-crosslinked polystyrene resin and 1-chloro-2-(dichloro(phenyl)methyl)benzene, which was easily obtained from 2-chlorobenzophenone. This 2-CTC resin showed excellent properties as a support for solid-phase peptide synthesis. Four peptide fragments were obtained in high purity using the resin. |
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