Stereochemical Prins cyclization: electronic versus steric effects on the synthesis of 2,4,6-trisubstituted tetrahydropyran rings |
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Authors: | Kok-Ping Chan |
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Institution: | Division of Chemistry and Chemical Biology, Nanyang Technological University, Singapore 637616, Singapore |
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Abstract: | A convenient approach towards the synthesis of both syn- and anti-2,4,6-chlorotetrahydropyrans has been developed. The electronic and steric influences on the stereochemistry of the Prins cyclized products were investigated based on the substituents of the homoallylic alcohol. |
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Keywords: | Prins cyclization anti-Tetrahydropyran Lone-pair inductive effect |
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