Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I |
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| Authors: | Mirela Călinescu Ticuţa Negreanu-Pîrjol Rodica Georgescu Octavian Călinescu |
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| Institution: | 1.Faculty of Chemistry,University of Bucharest,Bucharest,Romania;2.Faculty of Pharmacy,Ovidius University,Constan?a,Romania;3.Research Development National Institute for Physics and Nuclear,Engineering Horia Hulubei,Bucharest-M?gurele,Romania |
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| Abstract: | Three new copper(II) complex compounds with chlorhexidine diacetate as a ligand have been prepared and characterized by elemental
and thermogravimetrical analyses, molar conductances, magnetic susceptibility measurements, infrared, electronic and EPR spectra.
The complexes correspond to the formulas: Cu2(CHX)Cl4]·2C2H5OH, Cu2(CHX)Br4]·2C2H5OH and Cu2(CHX)(CH3COO)2] (CH3COO)2·2C2H5OH, where CHX = chlorhexidine, their composition and stereochemistry depending on the reaction conditions and the metal salt
used. Chlorhexidine acts as neutral tetradentate NNNN donor, coordinating through the four imine nitrogen atoms. Investigations
on antimicrobial activity in vitro show that all the complexes are active against the tested microorganisms, the complex with chloride being more active against
Gram negative bacteria than chlorhexidine diacetate..
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