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Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei |
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| Authors: | Xian-Wen Yang Lin Feng Jun-Mian Tian Xiao-Hua Liu Juan Su Wei-Dong Zhang |
| Affiliation: | a Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China b Department of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China c Department of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China d School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China |
| Abstract: | A novel biflavanol with unique six connective hexacyclic rings, abiesanol A (1), was isolated from the aerial parts of Abies georgei together with four known flavanols. The structure of new compound was elucidated mainly by the analysis of 1D and 2D NMR spectroscopic data. In addition, single-crystal X-ray diffraction analysis was adopted to confirm the structure of abiesanol A (1). In biological assay for inhibitory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, abiesanol A (1) showed potent effects at 50 μg/mL with the inhibition rate of 43.0%. Under the same concentration, abiesanol A (1) did not show any cytotoxicity against RAW264.7 macrophages. |
| Keywords: | Abies georgei Pinaceae Biflavanol Abiesanol A Nitric oxide (NO) RAW264.7 macrophages |
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