Advances in the preparation of porous polymer monoliths in capillaries and microfluidic chips with focus on morphological aspects |
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Authors: | Ivo Nischang Oliver Brueggemann Frantisek Svec |
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Affiliation: | (1) Institute of Polymer Chemistry, Johannes Kepler University Linz, Welser Strasse 42, 4060 Leonding, Austria;(2) The Molecular Foundry, E.O. Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA |
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Abstract: | Porous polymer monoliths have emerged as unique materials for many applications, including liquid-chromatographic analyses at an unrivaled speed, solid-phase extraction, and enzyme immobilization in capillary and microfluidic chip format. This article reviews the state of the art in the preparation of monoliths in narrow-bore capillaries and microfluidic chips and their miniaturization under conditions of spatial confinement. New developments in their preparation mainly using free radical polymerization techniques with a focus on morphological aspects in view of homogeneous porous materials are described. The suitability of monoliths for analysis of both large and small molecules is also discussed. |
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